Development of liver cancers is driven largely by genomic alterations that deregulate Nursery Art signaling pathways, influencing growth and survival of cancer cells.Because of the hundreds or thousands of genomic/epigenomic alterations that have accumulated in the cancer genome, it is very challenging to find and test candidate genes driving tumor
Increased expression of androgen receptor (AR) in prostate cancer (PC) is associated with transition to androgen independence.Because the progression of PC to advanced stages is often associated with the loss of p53 function, we tested whether the p53 could regulate the expression of AR gene.Here we report that p53 negatively regulates the expressi
The aim of this study was to evaluate the correlation between triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) hormones and thyroid gland volume with volumetric analysis performed by using computed tomography (CT) images.In this retrospective study, IV contrasted thoracic CT images taken for different indications between
Mutations in p53 and RAS potently cooperate in oncogenic transformation, and correspondingly, these genetic alterations frequently coexist in pancreatic ductal adenocarcinoma (PDA) and other human cancers.Previously, we identified a set Gifts of genes synergistically activated by combined RAS and p53 mutations as frequent downstream mediators of tu
The article discusses methods for calculating the moisture discharge voltage of insulators under various operating conditions (pollution, humidity, etc.) to identify patterns of environmental influence on operational characteristics, as well as to improve the reliability and safety of power grids.The main aim of the study is to compare two approach